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1

Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue

Hanessian, Stephen, Giguère, Alexandre, Grzyb, Justyna, Maianti, Juan Pablo, Saavedra, Oscar M., Aggen, James B., Linsell, Martin S., Goldblum, Adam A., Hildebrandt, Darin J., Kane, Timothy R., Dozzo,

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.06 MB

english, 2011

2

A Central Strategy for Converting Natural Products into Fluorescent Probes

Matthew D. Alexander, Michael D. Burkart, Michael S. Leonard, Padma Portonovo, Bo Liang, Xiaobin Ding, Madeleine M. Joullié, Brian M. Gulledge, James B. Aggen, A. Richard Chamberlin, Joel Sandler, Wil

Journal:

Year:

2006

Language:

english

File:

PDF, 694 KB

english, 2006

3

The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: rational modifications imparting PP1 selectivity

James B Aggen, John M Humphrey, Carla-Maria Gauss, Hsien-Bin Huang, Angus C Nairn, A.Richard Chamberlin

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 1.84 MB

english, 1999

4

Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones

Wagman, Allan S, Cirz, Ryan, McEnroe, Glenn, Aggen, James, Linsell, Martin S, Goldblum, Adam A, Lopez, Sara, Gomez, Marcela, Miller, George, Simons, Lloyd J, Belliotti, Thomas R, Harris, Christina R,

Journal:

Year:

2017

Language:

english

File:

PDF, 1.18 MB

english, 2017

5

Cover Feature: Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones (ChemMedChem 20/2017)

Wagman, Allan S., Cirz, Ryan, McEnroe, Glenn, Aggen, James, Linsell, Martin S., Goldblum, Adam A., Lopez, Sara, Gomez, Marcela, Miller, George, Simons, Lloyd J., Belliotti, Thomas R., Harris, Christin

Journal:

Year:

2017

File:

PDF, 968 KB

2017

6

A Multivalent Approach to Drug Discovery for Novel Antibiotics

Long, Daniel D, Aggen, James B, Christensen, Burton G, Judice, J Kevin, Hegde, Sharath S, Kaniga, Koné, Krause, Kevin M, Linsell, Martin S, Moran, Edmund J, Pace, John L

Journal:

The Journal of Antibiotics

Year:

2008

Language:

english

File:

PDF, 163 KB

english, 2008

7

Progress against Escherichia coli with the Oxazolidinone Class of Antibacterials: Test Case for a General Approach To Improving Whole-Cell Gram-Negative Activity

Takrouri, Khuloud, Cooper, Harold D., Spaulding, Andrew, Zucchi, Paola, Koleva, Bilyana, Cleary, Dillon C., Tear, Westley, Beuning, Penny J., Hirsch, Elizabeth B., Aggen, James B.

Journal:

ACS Infectious Diseases

Year:

2016

Language:

english

File:

PDF, 3.50 MB

english, 2016

8

Exploring the Positional Attachment of Glycopeptide/β-lactam Heterodimers

Long, Daniel D, Aggen, James B, Chinn, Jason, Choi, Seok-Ki, Christensen, Burton G, Fatheree, Paul R, Green, David, Hegde, Sharath S, Judice, J Kevin, Kaniga, Koné

Journal:

The Journal of Antibiotics

Year:

2008

Language:

english

File:

PDF, 311 KB

english, 2008

9

DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA

Wen Fan, Qi, Lorenzana, Edward, Luo, Xujun, Lea, Robin, Aksoy, Ozlem, An, Zhenyi, Ozawa, Tomoko, Wassarman, Douglas, Shokat, Kevan, Aggen, James, Smith, Jaqueline A M, Singh, Mallika, Butowski, Nichol

Journal:

Year:

2019

File:

PDF, 89 KB

2019

10

Regulation of protein phosphatase-1

James B Aggen, Angus C Nairn, Richard Chamberlin

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 283 KB

english, 2000

11

Congener-Independent Immunoassay for Microcystins and Nodularins

Fischer, Werner J., Garthwaite, Ian, Miles, Christopher O., Ross, Kathryn M., Aggen, James B., Chamberlin, A. Richard, Towers, Neale R., Dietrich, Daniel R.

Journal:

Environmental Science & Technology

Year:

2001

Language:

english

File:

PDF, 124 KB

english, 2001

12

Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety

Cohen, Frederick, Aggen, James B., Andrews, Logan D., Assar, Zahra, Boggs, Jen, Choi, Taylor, Dozzo, Paola, Easterday, Ashton N., Haglund, Cat M., Hildebrandt, Darin J., Holt, Melissa C., Joly, Kristi

Journal:

Year:

2019

Language:

english

File:

PDF, 2.30 MB

english, 2019

13

1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists

Pennell, Andrew M.K., Aggen, James B., Sen, Subhabrata, Chen, Wei, Xu, Yuan, Sullivan, Edward, Li, Lianfa, Greenman, Kevin, Charvat, Trevor, Hansen, Derek, Dairaghi, Daniel J., Wright, J.J. Kim, Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 485 KB

english, 2013

14

Total Synthesis of the Serine-Threonine Phosphatase Inhibitor Microcystin-LA

Humphrey, John M., Aggen, James B., Chamberlin, A. Richard

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 654 KB

english, 1996

15

Microcystin analogues comprised only of adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors

Brian M Gulledge, James B Aggen, Hugo Eng, Khuloud Sweimeh, A.Richard Chamberlin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 190 KB

english, 2003

16

Linearized and truncated microcystin analogues as inhibitors of protein phosphatases 1 and 2A

Brian M. Gulledge, James B. Aggen, A.Richard Chamberlin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 160 KB

english, 2003

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